CDC42EP2 Back

CDC42 effector protein (Rho GTPase binding) 2

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NCBI Description of CDC42EP2
CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control.

Community Annotation of CDC42EP2 Add / Edit CDC42EP2: Annotations

No community annotations yet for CDC42EP2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDC42EP2 is highly significantly mutated in
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CDC42EP2 is significantly mutated in
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CDC42EP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDC42EP2