CDC25A Back

cell division cycle 25 homolog A (S. pombe)

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NCBI Description of CDC25A
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CDC25A Add / Edit CDC25A: Annotations

No community annotations yet for CDC25A.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDC25A is highly significantly mutated in
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CDC25A is significantly mutated in
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CDC25A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDC25A