CDC14B Back

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

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NCBI Description of CDC14B
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

Community Annotation of CDC14B Add / Edit CDC14B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CDC14B is highly significantly mutated in
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CDC14B is significantly mutated in
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CDC14B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CDC14B