CD82 Back

CD82 molecule

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NCBI Description of CD82

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Community Annotation of CD82 Add / Edit CD82: Annotations

No community annotations yet for CD82.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CD82 is highly significantly mutated in
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CD82 is significantly mutated in
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CD82 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CD82