CD74 Back

CD74 molecule, major histocompatibility complex, class II invariant chain

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CD74

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Community Annotation of CD74 Add / Edit CD74: Annotations

No community annotations yet for CD74.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CD74 is highly significantly mutated in
CD74 is significantly mutated in
CD74 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CD74