CD70 Back

CD70 molecule

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CD70

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Community Annotation of CD70 Add / Edit CD70: Annotations

No community annotations yet for CD70.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CD70 is highly significantly mutated in
Diffuse large B-cell lymphoma
DLBCL
5 patients (8%)
CD70 is significantly mutated in
CD70 is near significance in
Colorectal
CRC
5 patients (2%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CD70