CD3D Back

CD3d molecule, delta (CD3-TCR complex)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CD3D

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

Community Annotation of CD3D Add / Edit CD3D: Annotations

No community annotations yet for CD3D.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CD3D is highly significantly mutated in
(none)
CD3D is significantly mutated in
(none)
CD3D is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CD3D