CD2BP2 Back

CD2 (cytoplasmic tail) binding protein 2

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NCBI Description of CD2BP2
This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined.

Community Annotation of CD2BP2 Add / Edit CD2BP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CD2BP2 is highly significantly mutated in
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CD2BP2 is significantly mutated in
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CD2BP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CD2BP2