CCR4 Back

chemokine (C-C motif) receptor 4

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NCBI Description of CCR4
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.

Community Annotation of CCR4 Add / Edit CCR4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CCR4 is highly significantly mutated in
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CCR4 is significantly mutated in
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CCR4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CCR4