CCNDBP1 Back

cyclin D-type binding-protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CCNDBP1
This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene.

Community Annotation of CCNDBP1 Add / Edit CCNDBP1: Annotations

No community annotations yet for CCNDBP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CCNDBP1 is highly significantly mutated in
(none)
CCNDBP1 is significantly mutated in
(none)
CCNDBP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CCNDBP1