CCL7 Back

chemokine (C-C motif) ligand 7

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NCBI Description of CCL7
This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. There is an upstream in-frame AUG at nt 46-48. This AUG was not annotated as the translation start baecuase it has a weak Kozak signal and is not conserved in vertebrates.

Community Annotation of CCL7 Add / Edit CCL7: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CCL7 is highly significantly mutated in
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CCL7 is significantly mutated in
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CCL7 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CCL7