CCL18 Back

chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

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NCBI Description of CCL18
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.

Community Annotation of CCL18 Add / Edit CCL18: Annotations

No community annotations yet for CCL18.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CCL18 is highly significantly mutated in
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CCL18 is significantly mutated in
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CCL18 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CCL18