CCDC88A Back

coiled-coil domain containing 88A

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CCDC88A
This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of CCDC88A Add / Edit CCDC88A: Annotations

No community annotations yet for CCDC88A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CCDC88A is highly significantly mutated in
(none)
CCDC88A is significantly mutated in
(none)
CCDC88A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CCDC88A