CBY1 Back

chibby homolog 1 (Drosophila)

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NCBI Description of CBY1

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CBY1 Add / Edit CBY1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CBY1 is highly significantly mutated in
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CBY1 is significantly mutated in
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CBY1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CBY1