CBX2 Back

chromobox homolog 2 (Pc class homolog, Drosophila)

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NCBI Description of CBX2
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Community Annotation of CBX2 Add / Edit CBX2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CBX2 is highly significantly mutated in
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CBX2 is significantly mutated in
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CBX2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CBX2