CBLC Back

Cas-Br-M (murine) ecotropic retroviral transforming sequence c

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NCBI Description of CBLC
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of CBLC Add / Edit CBLC: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CBLC is highly significantly mutated in
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CBLC is significantly mutated in
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CBLC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CBLC