CBFA2T3 Back

core-binding factor, runt domain, alpha subunit 2; translocated to, 3

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NCBI Description of CBFA2T3
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CBFA2T3 is highly significantly mutated in
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CBFA2T3 is significantly mutated in
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CBFA2T3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CBFA2T3