CATSPER2 Back

cation channel, sperm associated 2

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NCBI Description of CATSPER2
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CATSPER2 is highly significantly mutated in
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CATSPER2 is significantly mutated in
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CATSPER2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CATSPER2