CASP8AP2 Back

CASP8 associated protein 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CASP8AP2
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.

Community Annotation of CASP8AP2 Add / Edit CASP8AP2: Annotations

No community annotations yet for CASP8AP2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CASP8AP2 is highly significantly mutated in
(none)
CASP8AP2 is significantly mutated in
(none)
CASP8AP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CASP8AP2