CASC4 Back

cancer susceptibility candidate 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CASC4

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene.

Community Annotation of CASC4 Add / Edit CASC4: Annotations

No community annotations yet for CASC4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CASC4 is highly significantly mutated in
CASC4 is significantly mutated in
CASC4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CASC4