CASC3 Back

cancer susceptibility candidate 3

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NCBI Description of CASC3
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.

Community Annotation of CASC3 Add / Edit CASC3: Annotations

No community annotations yet for CASC3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CASC3 is highly significantly mutated in
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CASC3 is significantly mutated in
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CASC3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CASC3