CARD6 Back

caspase recruitment domain family, member 6

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NCBI Description of CARD6

This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.

Community Annotation of CARD6 Add / Edit CARD6: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CARD6 is highly significantly mutated in
CARD6 is significantly mutated in
CARD6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CARD6