capping protein (actin filament) muscle Z-line, alpha 3

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NCBI Description of CAPZA3

This gene encodes an actin capping protein, one of the F-actin capping protein alpha subunit family. The encoded protein is predominantly localized to the neck region of ejaculated sperm, other immunohistochemical signals were found in the tail and postacrosomal regions. The encoded protein may also form heterodimers of alpha and beta subunits. This protein may be important in determining sperm architecture and male fertility.

Community Annotation of CAPZA3 Add / Edit CAPZA3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


CAPZA3 is highly significantly mutated in
CAPZA3 is significantly mutated in
CAPZA3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for CAPZA3