CAPN11 Back

calpain 11

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NCBI Description of CAPN11

Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis.

Community Annotation of CAPN11 Add / Edit CAPN11: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CAPN11 is highly significantly mutated in
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CAPN11 is significantly mutated in
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CAPN11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CAPN11