CAPN1 Back

calpain 1, (mu/I) large subunit

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NCBI Description of CAPN1
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of CAPN1 Add / Edit CAPN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CAPN1 is highly significantly mutated in
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CAPN1 is significantly mutated in
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CAPN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CAPN1