CAMK2A Back

calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CAMK2A
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.

Community Annotation of CAMK2A Add / Edit CAMK2A: Annotations

No community annotations yet for CAMK2A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CAMK2A is highly significantly mutated in
(none)
CAMK2A is significantly mutated in
(none)
CAMK2A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CAMK2A