CALR3 Back

calreticulin 3

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CALR3
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy.

Community Annotation of CALR3 Add / Edit CALR3: Annotations

No community annotations yet for CALR3.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CALR3 is highly significantly mutated in
(none)
CALR3 is significantly mutated in
(none)
CALR3 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CALR3