CALHM1 Back

calcium homeostasis modulator 1

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NCBI Description of CALHM1
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.

Community Annotation of CALHM1 Add / Edit CALHM1: Annotations

No community annotations yet for CALHM1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CALHM1 is highly significantly mutated in
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CALHM1 is significantly mutated in
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CALHM1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CALHM1