CALCA Back

calcitonin-related polypeptide alpha

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NCBI Description of CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of CALCA Add / Edit CALCA: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CALCA is highly significantly mutated in
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CALCA is significantly mutated in
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CALCA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CALCA