CADPS Back

Ca2+-dependent secretion activator

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NCBI Description of CADPS
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.

Community Annotation of CADPS Add / Edit CADPS: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CADPS is highly significantly mutated in
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CADPS is significantly mutated in
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CADPS is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CADPS