CACNB2 Back

calcium channel, voltage-dependent, beta 2 subunit

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NCBI Description of CACNB2
This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CACNB2 is highly significantly mutated in
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CACNB2 is significantly mutated in
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CACNB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CACNB2