CACNA2D4 Back

calcium channel, voltage-dependent, alpha 2/delta subunit 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of CACNA2D4

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Community Annotation of CACNA2D4 Add / Edit CACNA2D4: Annotations

No community annotations yet for CACNA2D4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CACNA2D4 is highly significantly mutated in
(none)
CACNA2D4 is significantly mutated in
(none)
CACNA2D4 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for CACNA2D4