CACNA1B Back

calcium channel, voltage-dependent, N type, alpha 1B subunit

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NCBI Description of CACNA1B
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CACNA1B is highly significantly mutated in
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CACNA1B is significantly mutated in
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CACNA1B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CACNA1B