CABIN1 Back

calcineurin binding protein 1

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NCBI Description of CABIN1
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.

Community Annotation of CABIN1 Add / Edit CABIN1: Annotations

No community annotations yet for CABIN1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

CABIN1 is highly significantly mutated in
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CABIN1 is significantly mutated in
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CABIN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for CABIN1