C1S Back

complement component 1, s subcomponent

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NCBI Description of C1S

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


C1S is highly significantly mutated in
C1S is significantly mutated in
C1S is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for C1S