BUB1B Back

BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)

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NCBI Description of BUB1B
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Community Annotation of BUB1B Add / Edit BUB1B: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BUB1B is highly significantly mutated in
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BUB1B is significantly mutated in
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BUB1B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BUB1B