BUB1B Back

BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of BUB1B

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Community Annotation of BUB1B Add / Edit BUB1B: Annotations

No community annotations yet for BUB1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BUB1B is highly significantly mutated in
(none)
BUB1B is significantly mutated in
(none)
BUB1B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for BUB1B