BRMS1 Back

breast cancer metastasis suppressor 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of BRMS1

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Community Annotation of BRMS1 Add / Edit BRMS1: Annotations

No community annotations yet for BRMS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BRMS1 is highly significantly mutated in
BRMS1 is significantly mutated in
BRMS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BRMS1