BRF2 Back

BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like

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NCBI Description of BRF2

This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BRF2 is highly significantly mutated in
BRF2 is significantly mutated in
BRF2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BRF2