BRF1 Back

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)

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NCBI Description of BRF1

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified.

Community Annotation of BRF1 Add / Edit BRF1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BRF1 is highly significantly mutated in
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BRF1 is significantly mutated in
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BRF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for BRF1