BIRC2 Back

baculoviral IAP repeat-containing 2

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NCBI Description of BIRC2
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BIRC2 is highly significantly mutated in
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BIRC2 is significantly mutated in
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BIRC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BIRC2