BIN3 Back

bridging integrator 3

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NCBI Description of BIN3

The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.

Community Annotation of BIN3 Add / Edit BIN3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BIN3 is highly significantly mutated in
BIN3 is significantly mutated in
BIN3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BIN3