BEST4 Back

bestrophin 4

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NCBI Description of BEST4
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (bestrophin 1) is associated with vitelliform macular dystrophy. The bestrophin 4 gene is predominantly expressed in the colon.

Community Annotation of BEST4 Add / Edit BEST4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BEST4 is highly significantly mutated in
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BEST4 is significantly mutated in
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BEST4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BEST4