brain-derived neurotrophic factor

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NCBI Description of BDNF

The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Community Annotation of BDNF Add / Edit BDNF: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


BDNF is highly significantly mutated in
BDNF is significantly mutated in
BDNF is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for BDNF