BCL6 Back

B-cell CLL/lymphoma 6 (zinc finger protein 51)

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NCBI Description of BCL6

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Community Annotation of BCL6 Add / Edit BCL6: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BCL6 is highly significantly mutated in
BCL6 is significantly mutated in
BCL6 is near significance in
Diffuse large B-cell lymphoma
DLBCL
5 patients (8%)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for BCL6