BCL2 Back

B-cell CLL/lymphoma 2

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NCBI Description of BCL2
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.

Community Annotation of BCL2 Add / Edit BCL2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BCL2 is highly significantly mutated in
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BCL2 is significantly mutated in
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BCL2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BCL2