BCL11A Back

B-cell CLL/lymphoma 11A (zinc finger protein)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of BCL11A
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

Community Annotation of BCL11A Add / Edit BCL11A: Annotations

No community annotations yet for BCL11A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BCL11A is highly significantly mutated in
(none)
BCL11A is significantly mutated in
(none)
BCL11A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BCL11A