BANK1 Back

B-cell scaffold protein with ankyrin repeats 1

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NCBI Description of BANK1
The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.

Community Annotation of BANK1 Add / Edit BANK1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

BANK1 is highly significantly mutated in
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BANK1 is significantly mutated in
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BANK1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for BANK1