B3GNT3 Back

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

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NCBI Description of B3GNT3
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

B3GNT3 is highly significantly mutated in
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B3GNT3 is significantly mutated in
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B3GNT3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for B3GNT3