AWAT1 Back

acyl-CoA wax alcohol acyltransferase 1

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NCBI Description of AWAT1
The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin.

Community Annotation of AWAT1 Add / Edit AWAT1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

AWAT1 is highly significantly mutated in
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AWAT1 is significantly mutated in
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AWAT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for AWAT1