AUP1 Back

ancient ubiquitous protein 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of AUP1

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

Community Annotation of AUP1 Add / Edit AUP1: Annotations

No community annotations yet for AUP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


AUP1 is highly significantly mutated in
AUP1 is significantly mutated in
AUP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for AUP1